Topical creams containing lidocaine frequently cause stinging, burning, itching, and redness as adverse effects. Rarely, it may also result in an allergic response that manifests as hives, breathing problems, or swelling of the cheeks, lips, or tongue.
Lidocaine topical cream should not be used by anyone who is allergic to lidocaine or other ingredients in the cream. It should also not be used on broken or damaged skin, or in the eyes or mucous membranes. Additionally, children and pregnant women should not use lidocaine topical cream.